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Hyaluronic acid is often used in aesthetic medicine to improve the appearance of the skin. However, in the case of inadequate knowledge and inadequate injection method with cross-linked hyaluronic acid, certain complications may occur.

Hyaluronidase and complications after hyaluronic acid injections

Inappropriate injections with hyaluronic acid can cause negative effects. Their treatment is possible thanks to hyaluronidase. It is an enzyme that breaks down hyaluronic acid in the skin.

Most importantly, it is produced naturally by bacteria and cells in the human body, but it is also a component of wasp, hornet, bee, and sheep and bovine protein. It is currently the most effective way to treat the negative effects of improperly performed injections and filling with hyaluronic acid.

Hyaluronidase in Poland, is it worth it?


Do you want to heal the complications caused by an incompetent injection of hyaluronic acid?


Do you want to improve the appearance of your skin?


Is it important to you that the procedure is minimally invasive?



The basic indications for the hyaluronidase treatment are primarily complications of the previously administered hyaluronic acid or the dissolution of a poorly selected filler. The treatment is also recommended for patients who struggle with problems such as threatening necrosis of the skin and subcutaneous tissue, caused by the administration of hyaluronic acid, visual disturbances, violent allergic reaction, occurrence of cocci, asymmetry, biofilm formation, occurrence of organism intolerance to the previously administered hyaluronic acid, undesirable effect of filler displacement, excessive amount of hyaluronic acid filler, maintaining swelling due to water retention at the place of filler application, the appearance of lumps and unevenness caused by a earlier, and shallow administration of hyaluronic acid.



The application of the enzyme hyaluronidase is not always possible. The contraindication is, inter alia, allergy to insect venom or bovine and sheep proteins, damage or ulceration of the skin surface in the treated areas, fungi, viral and bacterial infections. If the patient is at risk of skin and / or subcutaneous tissue necrosis or other very serious complication, the only contraindication is the refusal to consent to the medical intervention.

In the case of the planned administration of hyaluronidase, another contraindication is also the unrealistic expectation of the results that can be obtained, arterial hypertension, autoimmune diseases, pregnancy and breastfeeding, or active cancer.

The procedure

The treatment does not require any preparation – you should go to the doctor without makeup, and he will disinfect the area where the enzyme will be applied, immediately before the injection. Before the application of hyaluronidase, consult a doctor who will perform a detailed medical history and ensure the proper course of the procedure.

In cases where there are any indications for the application of the enzyme (impending skin necrosis), hyaluronidase is administered without conducting an allergic test. A small amount of hyaluronidase is administered to the forearm area. The site is then monitored for an adverse allergic reaction. If there is no disturbing phenomenon, the hyaluronic acid will be dissolved after 15-30 minutes.

The enzyme is applied by using a fine needle. The injection takes place in the area where the filler was previously injected – lips, nose area, etc. The substance is administered in a small amount, directly to the papule formed after the administration of hyaluronic acid. Occasionally, small swellings or bruises appear after injecting the enzyme, but they disappear very quickly. Some of the patients react to hyaluronidase with a local inflammatory skin reaction, urticaria.

Benefits of Hyaluronidase

The hyaluronidase treatment is appreciated all over the world. This is due to the advantages it offers. Among the most important, the following are distinguished:

  • The effectiveness and durability of the treatment – hyaluronidase is the most effective treatment, which allows you to dissolve the previously applied hyaluronic acid. Thanks to this, after the procedure, the patient can enjoy a clearly improved quality of life and the reduction of unsatisfactory results.
  • Improving the patient’s well-being and self-esteem – the purpose of the treatment is to dissolve hyaluronic acid. As a result, the patient can get rid of the unsatisfactory aesthetic effect and gain more self-confidence.
  • Painless and safe – the procedure of administering the hyaluronidase enzyme is not a threat to the patient’s life and health. Experienced specialists make sure that the results are as satisfactory as possible.

The effects

The results of the treatment are visible immediately after its performance. Unfortunately not very accurately. Administration of hyaluronidase usually generates a slight swelling, which, however, disappears after a few hours. If the acid was applied very superficially or there were changes in the form of lumps, the progress of dissolution can still be seen in the doctor’s office.

The first 6 hours after the procedure, it is strictly prohibited from touching the areas where the injection of the enzyme was concerned. 72 hours from its performance, you should not massage, rub or scratch the treated areas of the body. The full effect becomes visible just after 72 hours. Hyaluronidase dissolves hyaluronic acid as a filler and the skin’s own acid. The whole process takes about 3 weeks, after which the cavity is gradually rebuilt. The improvement in the skin condition is usually visible from 1 to 7 days after the treatment. The body excretes and metabolizes the enzyme within one week of the application of hyaluronidase.

One treatment is usually enough to obtain satisfactory results. 72 hours after the application of the enzyme, the doctor assesses the obtained results. He can then decide whether to reapply hyaluronidase.

Administration of hyaluronidase is not a threat to the life and health of the patient, provided that it is carried out by a specialist. Administration of the enzyme is associated with a certain risk of adverse reactions (just like any interference in the body). The form that is most life-threatening is an allergic reaction. That is why it is so important that the procedure is performed by qualified doctors.

If you want to eliminate complications caused by improper injections of hyaluronic acid in a minimally invasive way, hyaluronidase is a treatment that is dedicated to your needs!