TL;DR:
- Platelet-rich fibrin (PRF) uses the patient’s blood to stimulate skin regeneration, producing collagen, elastin, and hyaluronic acid for firmer, smoother skin.
- It treats wrinkles, scars, skin laxity, dark circles, hair loss, and more, improving skin tone, hydration, and elasticity 3 months post-treatment.
- Popular methods include deep mesotherapy and nappage injection, requiring hydration and preparation before treatment.
- PRF includes stem cells (HSCs and MSCs) that aid tissue regeneration through angiogenesis and formation of new cells like chondroblasts and osteoblasts.
- Not suitable for pregnant women or patients with severe conditions (e.g., diabetes, cancer).
- Typically safe, with minimal side effects like redness or swelling, and minimal downtime.
- Combining PRF and platelet-rich plasma enhances long-lasting effects for deeper regeneration.
Platelet-rich fibrin is an innovative pacemaker treatment that has been used in aesthetic medicine for a long time and is gaining increasing recognition among clients. This is due to the numerous advantages that fibrin offers while reducing the risk of graft rejection. What is it used for and what results does it provide? We explain!
What is platelet-rich fibrin
Platelet-rich fibrin uses the patient's natural blood supply to stimulate the regenerative and revitalizing processes of the skin. It is obtained by taking a small amount of a person's blood and then separating the fibrin from other blood components. For this purpose, a special draining technique is used. This stimulator contains a high concentration of platelets, which are rich in valuable growth factors and other bioactive substances. After the fibrin is applied, the growth factors have a direct effect on adipose tissue and stimulate the production of collagen, elastin or hyaluronic acid. As a result, the skin gains firmness, elasticity, and wrinkles and fine lines are reduced. Fibrin treatments are used on different areas of the body and for different purposes. Aesthetic medicine makes it possible to use the stimulator to treat scars, improve the elasticity of the skin on the face, neck and décolleté, or reduce dark circles under the eyes. It is also a popular treatment for baldness in men and women. 
Platelet-rich fibrin is thus a concentrated mixture of stem cells, growth factors and leukocytes. It is these elements that are involved in stimulating biological regeneration in skin tissues. With the intradermal application of plasma by deep mesotherapy or the subcutaneous nappage technique, there is a slow coagulation into a gel, which is a natural autologous substance that fills selected areas of the skin. As a result of activated growth factors and mesenchymal stem cells, **platelet-rich fibrin has a regenerative effect.
The stem cell content of fibrin makes fibrin treatments highly effective. These cells have an unlimited capacity for cell division. They also assume the functions specified for the tissues of a particular body structure. Platelet-rich fibrin treatments use such types of stem cells as:
- hematopoietic HSCs, which are obtained from the patient's centrifuged peripheral blood. When injected into tissues, these cells activate proliferation. They also differentiate to take on the cellular functions of other tissues – this is known as plasticity,
- Mesenchymal MSCs, which are derived from muscle tissue, skin tissue, hair follicles or capillaries. They activate when cell fibrin is applied to selected tissues. They then create new, missing cell lines through regenerative processes. This process results in the formation of new chondroblasts, osteoblasts and adipocytes.
Treatments using platelet-rich fibrin plasma are also popular Both of these autologous materials are obtained from the patient's blood. They are platelet concentrates with many factors that accelerate angiogenesis – the formation of new blood vessels and cell formation. The combination of plasma and fibrin allows to increase the potency of both factors, which in turn provides long-term treatment effects – deep skin regeneration, wrinkle reduction or prevention of baldness treatment.
What are the indications for platelet-rich fibrin treatments?
Platelet rich fibrin is recommended for people who want to rejuvenate their skin, speed up the healing of the skin after the procedure and the recovery time itself. It is also a great way to help treat baldness and hair loss. The treatment can be performed on both ladies and gentlemen of different ages whose skin has to face environmental factors. Application of this stimulator will also be an effective weapon in the fight against:
- wrinkles,
- nasal and lip furrows,
- lost skin firmness,
- dark circles in the eye area,
- dryness of the skin,
- lack of radiance and vitality,
- wounds and scars
- excessive hair loss,
- baldness.
The therapy will also be an excellent complement to laser treatments. The effects of combined treatments can be seen much faster, and recovery time is shortened. Also popular is platelet-rich fibrin under the eyes, which reduces dark circles in this area. It evens out the skin tone and restores its normal elasticity or tone. As a result, the look regains clarity and freshness.
What are the contraindications to the use of platelet-rich fibrin?
Platelet rich fibrin as with other treatments, is not recommended for all people. Doctors advise against the therapy in pregnant and breastfeeding women. Also contraindicated are various medical conditions – especially chronic ones with a severe course. These include diabetes, cardiovascular disease or active inflammation and cancer, among others.
What does platelet-rich fibrin treatment consist of?
Treatment with platelet-rich fibrin is free of side effects or allergies, but just like any other treatment, it requires a certain amount of preparation from the patient. First of all, it is necessary to take care of increased blood flow in the body and obtain a better concentration of the stimulator in the centrifuged concentrate. That's why it will be a good idea to hydrate regularly for a few days before the procedure, drinking at least 2 liters of water every day. It is also recommended to avoid dehydrating agents (coffee, alcohol). Before treatment with this stimulator, a consultation with an aesthetic physician is also required. Once the specialist qualifies for treatment, blood is drawn from the patient's ulnar fossa, which is later centrifuged to extract fibrin. Typically, the intradermal puncture point technique and the nappage method are used. In the former, a 0.5 mm – 2.5 mm deep injection is performed along the line of wrinkles or furrows every 5 – 10 mm. After treatment, it is recommended to stop using irritating cosmetics. You should also limit the use of swimming pools and saunas for at least a week. Special care is also required for hygiene of the sites where the product was applied. For several hours after the therapy, subcutaneous swellings may be visible at the injection site. However, this is not a cause for concern, as they spontaneously subside within a few hours of treatment. Redness in the areas undergoing regeneration is also a natural occurrence. Usually, however, platelet-rich fibrin therapy does not require a long recovery time.
What results can be obtained after platelet-rich fibrin treatment?
The first effects of platelet-rich fibrin and plasma can be seen about 3 months after the treatment series. Depending on the place where the product was administered, the patient can get the result of a pronounced smoothing of the skin, improvement of its elasticity or tension. The condition of the skin improves significantly and a change in hydration can be noticed in the treatment area. In addition, Patients observe in themselves a gentle filling of the tissue or the formation of a natural network, in the area of which skin repair processes take place. An equally important effect is the slow release of platelet growth factors and stimulation of regeneration. In the case of a treatment combining fibrin and plasma, there is in turn an increase in the potency of both factors, which in turn provides stronger and longer-lasting effects. The result is profound skin regeneration, improved skin tone, hydration and tightness. There is also a reduction in wrinkles. At the OT.CO Clinic, we provide access to modern techniques in the field of aesthetic medicine, which are designed to visibly improve the condition of the patient's skin. One of them is precisely platelet-rich fibrin and platelet-rich plasma – blood-derived materials. Their great advantage is that they are derived from the Patient's own blood, so any risk of rejection of the transplant is reduced to a minimum.
Conclusion
Platelet-rich fibrin is a powerful, natural treatment with clear, visible effects. It boosts skin renewal, reduces wrinkles, and treats hair loss using your own resources. By combining fibrin and plasma, you gain deeper, longer-lasting results while minimizing risks. This method addresses multiple concerns, like scars, fine lines, and skin tone, with numerous applications throughout the body. With its regenerative power and safety, platelet-rich fibrin offers a promising path to healthier, refreshed skin. It’s innovative, reliable, and tailored just for you, making it a standout in modern aesthetic medicine.
